Endocrine Abstracts

Patients with endocrine-related cancers are notably at increased risk for developing osteoporosis as a complication from their adjuvant anticancer treatment, especially aromatase inhibitors (AIs) in early breast cancer (EBC) and androgen deprivation therapy (ADT) in early prostate cancer (EPC). AI-induced bone loss (AIIBL) occurs at a rate at least 2-fold higher than bone loss seen in healthy, age-matched postmenopausal women and they have a more than 30% higher risk of fractu...

Normal position of the testes at term birth is on the bottom of the scrotum. In 2–9% of newborn boys, the testes have failed to descend normally (cryptorchidism), and at the age of three months, 1–3% of all boys remain cryptorchid. Thereafter spontaneous descent occurs rarely, whereas testicular ascent starts to appear and acquired cryptorchidism becomes a problem almost as often as congenital disorder. Cryptorchidism is associated with an increased risk of testicula...

The thyroid hormone receptor (TR) belongs to a family of transcription factors which activity is modulated by the presence or absence of their particular ligand. Additionally, the transcriptional activity of TR is modulated by post-translational modifications such as phosphorylation, acetylation or ubiquitination. Here, I investigate whether TR might also be regulated by sumoylation. Sumoylation of transcription factors at defined lysine residues often leads to an alteration o...

Introduction: Growth is an important and sensitive indicator of child health. Abnormal growth is a common consequence of many conditions, therefore its identification acts as a useful warning of possible pathology. Effective growth monitoring requires precise linear growth measurements; however, measurements are often inaccurate and unreliable. Measurement error influences the interpretation of growth patterns resulting in failure to identify underlying pathology or apparent g...

Pathologies of pituitary gland are often revealed by diabetes insipidus. Etiologies are, in first, tumors, inflammatory and granulomatosis diseases after, but stay idiopathic in 24% of French study, 52% of Italian study and 33% of Tunisian study.Case report: Mrs A., 53 years old, consults in 1998 because polyuria–polydipsia, without diabetes mellitus. She is hospitalized during 2 days and hydric restriction test shows the organic reality. The others...

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TSHR autoantibodies with stimulating (agonist) activity cause the hyperthyroidism of Graves’ disease, while the rarer blocking (antagonist) type TSHR autoantibodies are responsible for hypothyroidism in some patients. We have isolated four human monoclonal autoantibodies (MAbs) which bind the TSHR with high affinity. Two antibodies, M22 and K1-18 have potent thyroid stimulating activity, one MAb K1-70 has strong antagonist (blocking) activity and the fourth MAb 5C9 has st...

Bariatric surgery has become the most effective therapeutic option for morbid obesity (BMI > 40 or >35 with major complications). All established surgical techniques are followed by significant body weight reduction as well as clear improvement /remission of main obesity-associated comorbidities such as type 2 diabetes (DM2), dyslipidaemia, hypertension, sleep apnoea and cardiac dysfunction. Mixed restrictive-malabsorptive techniques, such as Roux-en Y-gastric bypass (...

Introduction: Prolactinoma account for 40% of all pituitary tumors. It is the most common cause of hyperprolactinemia. Infertility, galactorrhea and hirsutism are the significant symptoms. Polycystic ovary syndrome affects the 5–10% of the women in reproductive age. The most common symptoms are irregular menses, hirsutism and infertility. However, prolactinoma and PCOS association is rare. A case of PCOS and prolactinoma is reported.Case: A 21-year-...